I am a cancer biologist trained in epigenomics, working to understand how brain tumours rewire the chromatin states that emerging molecular therapies can target.
My research centres on diffuse midline glioma: a paediatric brain tumour that is uniformly fatal, with median survival under a year. These tumours are defined by a single mutation in histone H3 that reorganises the entire tumour epigenome, locking cells in an immature, tumorigenic state.
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2026 · Nature Genetics
H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs
2021 · Trends in Cell Biology
Polycomb repressive complex 2 in the driver's seat of childhood and young adult brain tumours
2019 · Cancer Cell
Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas
2025 · Nature Communications